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CBD and Bioavailability

CBD and Bioavailability

Explaning CBD and Bioavailability

Times are exciting in the world of CBD right now. As an emerging therapy, research is well underway, looking into its potential health benefits.

Researchers are still exploring how CBD can relieve certain health conditions, and how much CBD is required to be effective. Beyond how much, there’s also the question of simply how. Is there a “best” way to take CBD?

The conversation about the “best” way to take CBD almost always touches on the topic of bioavailability. But what is bioavailability, and how does it affect your experience with CBD oil? We explore below. 

What does bioavailability mean?

Bioavailability refers to how much, and at what rate, something gets absorbed by your bloodstream. It’s important to understand the bioavailability of a substance because it helps you determine how much you need to take—and in what form—to ensure a proper dose actually ends up in your system. Otherwise, you may not feel the desired effects.

What is the bioavailability of CBD oil?

The bioavailability of CBD oil largely depends on the method of administration you use to administer it—in other words, how you consume the CBD. There are many ways to take CBD, from gummies and edibles to vapes. Each of these methods has a different bioavailability.

CBD intranasal bioavailability

CBD has an intranasal bioavailability of 34% to 46%, although some studies have reported rates as high as 56%. Inhaling CBD is the most effective method for ensuring a high bioavailability.

When CBD is inhaled, such as through a vape pen or vaporizer, it can be absorbed through your lungs nearly immediately. From there, the CBD directly enters your bloodstream, allowing it to travel and bind to the appropriate endocannabinoid receptors throughout your body. With each subsequent breath, you inhale more CBD, providing yourself with a continuous dose of CBD that can be absorbed quickly (within minutes) and efficiently (direct entry through the lungs).

Intranasal Bioavailability of CBD
Product TypesBioavailability Rate
CBD vape oils
CBD vape pens
CBD vaporizers
34% to 46%, up to 56%

Effects felt within 10 minutes

CBD sublingual bioavailability

When administered sublingually (via drops held beneath the tongue), CBD oil has a sublingual bioavailability of 13% to 19%, with some studies putting it as high as 35%. Holding the CBD beneath your tongue allows it to be absorbed by your sublingual gland, through which it can enter the bloodstream and begin working its effects. While not quite as expedient as the inhalation method, sublingual administration of CBD still produces effects fairly quickly, within 20 minutes or so.

Of course, the trick here is to hold the CBD in the appropriate place (beneath the tongue) for an appropriate amount of time (30 to 60 seconds). If you swallow too soon, or apply the drops above your tongue and swallow quickly, you may as well be taking the CBD orally—which, as we’ll review in the next section, offers significantly lower bioavailability.

Sublingual Bioavailability of CBD
Product ExamplesBioavailability Rate
CBD tinctures
CBD sprays
13% to 19%, up to 35%

Effects felt within 5 to 20 minutes

CBD oral bioavailability

Oral ingestion is popular because it’s a method people are already familiar with, from eating food, drinking beverages, and swallowing daily vitamin. Unfortunately, while oral ingestion may be common, it’s also the least effective method for taking CBD. The oral bioavailability of CBD is between 10% to 20%, although some studies have found it to be as low as 6%.

Why is CBD’s oral bioavailability so low? When you consume CBD orally, it must pass through your digestive system first, before it ever reaches your bloodstream. This process is not a quick one—taking up to 2 hours for some people—and during it, some of the CBD gets lost to the liver and digestive tract. As a result, you’ll have to wait longer for the CBD to provide relief, and the relief it does provide may not be as effective (since so much was lost during the journey).

Oral Bioavailability of CBD
Product ExamplesBioavailability Rate
CBD edibles, like chocolate or baked goods
CBD concentrate added to water or food
CBD capsules
CBD gummies
6% to 20%

Effects felt within 30 to 120 minutes

Can you increase the bioavailability of CBD?

You can’t really increase the bioavailability of CBD. What you can do, however, is optimize your method of administration to ensure you receive your ideal dose of CBD.

Keep in mind that all of the bioavailabilities listed above were achieved by expert researchers trained in administering the kind of hyper-precise doses required in scientific study. Your experience administering CBD to yourself may vary. But, you can still use these as a guide.

When taking CBD products at home, try multiplying the bioavailability rate by the amount of CBD in a serving size. The result of this calculation is closer to the “true” dose you’ll receive. Once you know the “true” dose, you can adjust your serving size accordingly. For example:

  • A 1000mg tincture, where a full 1ml dropper provides a serving size of 33.3mg of CBD, may actually deliver 6mg to 13.5mg of CBD.
  • A 300mg pre-filled vape cartridge, if smoked all at once, may deliver a dose of 102mg to 138mg of CBD.

If you’re using CBD topicals, remember that their bioavailability is quite low, so you may have to experiment to find an effective dose. By their nature, dosing with CBD topicals is imprecise. Most brands will direct you with vague instructions like “apply a finger-sized amount” or “use liberally. Follow their instructions, but also be aware that you may require a higher-dose product than you expect, simply because it’s harder for the CBD to break through the skin.

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The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product. The Federal Food, Drug and Cosmetic Act requires this notice. Our website showcases our entire product catalog. Our cannabidiol products are available for purchase at Cannabidiol (CBD) is a natural component of hemp oil.


This website contains general information about diet, health and nutrition. The information is not advice and is not a substitute for advice from a healthcare professional. Read the full disclaimer here.
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